在兩天我就要把這篇論文給搞懂並且做成power point
然後上台報告給教授和同學們聽，
天殺的書討[:|]
我看我都不用睡覺了，
然後最近又感冒好嚴重呢。
以下的內容摘要只是整份的40分之1....
Bone integrity is maintained by a dynamic equilibrium between
the activities of bone-forming osteoblasts and boneresorbing
osteoclasts. Osteolytic lesions are a painful consequence
of metastasis of breast cancer cells to bone in an
overwhelming majority of breast cancer patients. Factors secreted
by breast cancer cells propel a cascade of events that
trigger osteoclastogenesis and elevated bone resorption. In the
present study, we show that the Hedgehog (Hh) ligands secreted
by breast cancer cells promote osteoclast differentiation
and potentiate the activity of mature osteoclasts. Paracrine Hh
signaling induced by breast cancer cells mediates a detrimental
chain of events by the up-regulation of osteopontin (OPN),
which in turn enhances osteoclastic activity by up-regulating
cathepsin K and MMP9. Hh signaling is essential for osteoclasts
because blocking the Hh pathway using the pharmacological
Hh inhibitor, cyclopamine, results in an overall decrease
in osteoclastogenesis and resorptive activity. Our
studies suggest that inhibiting Hh signaling interferes with the
ability of pre-osteoclasts to respond to the stimulatory effects
of the breast cancer cells, indicating that Hh signaling is vital
to osteoclast activity.
住戶編號:2016091
檢舉原因
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